The Lancet paper showed that if you were treated early enough and took the drug as prescribed (it only works if you take it), it was shown to reduce your chance of death by 12X making it far more effective than any other drug for COVID. The web value rate of skirsch.io is 2 . The sooner you start, the better the outcomes. Doctors wait for government permission (EUA or added to the NIH guidelines) before using a drug. Most recent articles first. As of January 18, 2021, the CDC estimates that 90,000 Americans will die from COVID in just the next 3 weeks. It is currently approved for treatment of depression and obsessive compulsive disorder (OCD). So the drug had no chance of working (since there were no events), so the trial was stopped for futility, NOT because the drug doesnt work. Telling the truth, he tweeted. Fluvoxamine public data repository - Google Drive, On Cytokines, Fluvoxamine and COVID-19 Part 1, Jon-Emile S. Kenny MD[@heart_lung] You see, we have a kind of allergy to the past; its our national disease, and the very assurance with which you insist that the past is within the present is l, On Cytokines, Fluvoxamine and COVID-19 Part 2, Jon-Emile S. Kenny MD[@heart_lung] Apocalypse is played out now on a personal scale; it is not in the sky above us, but in our bed. -Mark Doty Introduction With a proposed pathway coupling patho, Effect of Fluvoxamine vs Placebo on Clinical Deterioration in Outpatients With Symptomatic COVID-19, This randomized trial compares the effects of fluvoxamine, a selective serotonin reuptake inhibitor with immunomodulatory effects vs placebo on a composite of dyspnea or pneumonia and oxygen desaturation among adult outpatients with polymerase chain reactionconfirmed mild coronavirus disease 2019 (, Prospective cohort of fluvoxamine for early treatment of COVID-19, Abstract. I learned this the hard way. Items included in the Television News search service. Here's why. (Siliciano did not respond to requests for comment for this article.). It was completed in August. One Silicon Valley entrepreneur thought he could beat the odds. All this was known back in January 2021 when a key opinion leader panel of experts from NIH, CDC, FDA, academia, and journal editors voted by over 2:1 to recommend that fluvoxamine be recommended to physicians to discuss with patients. Repurposed drugs are safer and more effective than the current vaccines. Steve Kirsch is looking for an explanation for 171,000 excess deaths. 47).. Steve Kirsch Nov 5, 2021 145 92 Here are the key things you should know about fluvoxamine for COVID: It works. People are dying because of physician fear of a new treatment with a 100% success rate and a solid mechanism of action. Most doctors wont use it until NIH greenlights it, no matter what the science says. See the repository above. Several former members told me he began relentlessly pressuring them to promote the drug in media stories, often during exhausting, circuitous conversations. Generally, at 50mg BID x 14, it is very tolerable as long as the patient is instructed to lay off the caffeine. Fauci wants the vaccine to be the only option, Cliff Lane works for Fauci, and Cliff follows his orders. They were all given the drug soon after symptoms and the placebo group was pure in that they were not taking any COVID drugs. Steve Kirsch is baffled. Has it really been 25 years, a whole quarter of a century? But a panel of key opinion leaders from the NIH, CDC . Fluvoxamine works on hospitalized patients too, but no US hospital will let you use it (sound familiar? When the pandemic started, he created the COVID-19 Early Treatment Fund (CETF) to fund researchers working on repurposed drugs including fluvoxamine which reduces death from COVID by a factor of 12. Steve wanted to say, Look, Ive got all these famous [infectious disease] docs and researchers, and they all say give fluvoxamine a chance, Judith Feinberg, one of the former CETF advisory board members and vice chair of research at the West Virginia University School of Medicine, told me. . I bumped up the reward to $1M. Steve Kirsch, current director of the Covid 19 Early Treatment fund is an MIT alumni who has made a career as a tech entrepreneur. But the best way to help people is through rigorous trials that show what drugs help which people, and at what doses and timesnot by basing entire protocols on incredibly limited evidence. just like ivermectin). . Why fluvoxamine isnt used. Most recent articles first. In other cases, stop cold turkey. 90,000 people will die in the next 3 weeks alone if we continue to ignore this drug that has caused no harm. . But they will refuse to give it to you even after being proven in a Phase 3 trial that was approved by the WHO. So when a group of scientists applied for an EUA for fluvoxamine, what did the FDA do? Everyone says "we need more data" to show fluvoxamine works for COVID. Its whether Merck can make a killing that matters. Discover special offers, top stories, If you cant get a prescription for COVID, then perhaps you have OCD? 1:49 If you start 5 days after symptoms, all bets are off. So far, doctors have failed to share his sense of urgency. He told me that while he and his family got vaccinated as soon as they were eligible, he got the idea that vaccines are dangerous from a man he hired to clean his carpets, who got very sick after receiving the vaccine. But they dont want their names used. Seftel was able to duplicate the 100% protection from hospitalization and death in the treatment group, vs. a 12.5% hospitalization/death rate for the No treatment group. And that is what has allowed Kirsch, and people like him, to become so influential. After two weeks (since it was a tight knit community, everyone could see what was happening to the two groups), every track worker who got sick with COVID, demanded the drug. The differences are obvious to untrained eyes. The combined p value of the two studies is <.0001. It was tested in. They rejected the drug for insufficient evidence just like they always do for ivermectin. It should be crystal clear to everyone that the current CDC guidelines for treating COVID aren't working. At the dosing for COVID (50mg BID x 14 days), there is a 1% chance of mild-nausea and because the dose is so low and the time it is taken is so short, and there are no psychotropic effects (which require more than 3 weeks of use; the psychotropic effects non-existent if you don't have depression or an anxiety disorder in the first place). NIH and WHO refuse to acknowledge it works since it will cause vaccine hesitancy if it is known that there is a drug that turns COVID into a mild disease. On his blog, Covid-19 Data Science, he has extensivelyand mercilesslyunpacked Kirschs evidence for the vaccine death claims. @stkirsch. Why not fluvoxamine? Quick Summary . Its not about the science. He's discovered a common medication that's highly effective in minimizing the impacts of COVID-19 - two studies have proven so. That study was featured on 60 Minutes. customer-service@technologyreview.com with a list of newsletters youd like to receive. This is a more comprehensive look at the key evidence supporting fluvoxamine: Hear from the doctors who did the studies directly as well as the Dean of Medicine at Emory University: List of the best evidence-based COVID treatment options. Generally, at 50mg BID x 14, it is very tolerable as long as the patient is instructed to lay off the caffeine. The repository goes over the prescribing guidelines, contraindications, and describes the effect on caffeine consumption while on drug (basically you want to avoid caffeine while on the drug). One is to reduce the threat of nuclear war. Yeah, its possible, he told mehe also says that he has regularly seen Kirsch manipulate evidence so that it seems to support claims that are, in reality, baseless. At the end of May this year, Siliciano emailed the other advisors to say that Kirsch had gone off the deep end and he was cutting ties. By the beginning of September, he was no longer the companys CEO, replaced by his co-founder, Marten Nelson. Its a cycle that feeds mistrust and boosts the profiles of influencers who present themselves in opposition to official authorities. He is very smart, and knows that he is very smart, and sometimes he behaves like he thinks he's the smartest guy in the room, whether he is or isn't., Kirschs response was to take his name off articles hed written about vaccine deaths, changing the authorship to VaccineTruth., On July 1, he tweeted from his personal account, My publicly shared concerns regarding the safety of the COVID-19 vaccines may have had a negative impact on my company, M10. There were no studies reported out so far where fluvoxamine made things worse or neutral. Think about it Molnupiravir has a 50% risk reduction whereas fluvxoamine is over 90%. I have all of these on hand and I load up on vitamin D3 every day. At the beginning of the COVID-19 pandemic, Steve Kirsch created the COVID-19 Early Treatment Fund (CETF) to finance trials of off-patent drugs in an attempt to find a potent treatment that had been staring us in the face. Vitamin D, NAC, betadine, aspirin, and Nigella sativa are all super cheap, effective, and available without a prescription. Its the gold standard of medical evidence. Drug interactions should be checked for. Fluvoxamine is used commonly to treat obsessive-compulsive disorder (OCD), social anxiety disorder and depression. . A very short op-ed arguing for using fluvoxamine against COVID. Fluvoxamine was reportedly added to just 2 practice guidelines (. In severe cases, it takes longer. So it was both obvious and convincing the difference between the groups to the workers and the track management. Steven Todd Kirsch is an American entrepreneur. It is about following orders and making money for the drug companies and protecting the doctor from liability and losing his medical license. Decreasing the dosage or stopping the medication will mitigate symptoms within hours. Timing is everything with respect to outcomes. MisinformationKills. Quick Summary . fluvoxamine The fast, easy, safe, simple, low cost treatment for COVID that has worked 100% of the time to prevent hospitalization that nobody wants to talk about We now have a viable solution to reduce COVID hospitalization and mortality; Read More fluvoxamine Got COVID? Online. Other drugs in this class include Prozac (fluoxetine), Zoloft (sertraline) and Paxil (paroxetine). There are at least eight mechanisms of action that we think contribute to the effectiveness of this drug. Last Checked: 03/02/2023. In October, the group reported that, while a few patients in the placebo group ended up in the hospital, none of the patients receiving fluvoxamine got sick enough to go. Medium banned him for misinformation. 707. Fluvoxamine is a well-tolerated, widely available, inexpensive selective serotonin reuptake inhibitor that has been shown in a small, double-blind, placebo-controlled, randomized study to prevent clinical deterioration of patients with mild coronavirus disease 2019 (COVID-19). P-value was 10^-14 on that study (done by Dr. Theyre finding alternative leaders to follow, Morris said. Their willingness to lie did. Pretty much nothing changed when the Phase 3 trial confirmed fluvoxamine worked. Answer (1 of 2): Yes, In a preliminary study of COVID-19 patients with mild-to-moderate disease who were attempting to recover in their homes, researchers at Washington University School of Medicine in St. Louis have found that the drug fluvoxamine seems to prevent some of the most serious compli. The trials that were abandoned for futility werent getting events because the patients were given standard of care meds. Or just depression about the vaccine mandates? Doing something is better than nothing. Here is what, e) which concluded: Under a variety of assumptions, fluvoxamine shows a high probability of preventing hospitalization in outpatients with COVID-19., For more about fluvoxamine (and other SSRIs that work), see, fluvoxamine completed a Phase 3 study showing it works that was published in the Lancet Global Health, NIH basically dismissed the fluvoxamine study as I predicted they would, few people werent afraid of expressing their displeasure, the highly acclaimed Bangladesh mask study showed, Johns Hopkins has incorporated fluvoxamine in their treatment guidelines, Ontario has become the first province to list fluvoxamine as a treatment doctors can consider for patients. In 2013, Johnson & Johnson paid $2.2 billion for its own kickback and fraud scandal, including a specific $400 million fine for its subsidiary Janssen, which manufactures the covid vaccine. Nobody who took the drug got sick at all, most all wanted to return to work within 3 days after starting treatment. It was approved by the FDA in 1994 and has been used in millions of patients worldwide. Fluvoxamine is way better than Molnupiravir, but the NIH doesnt approve drugs on effectiveness. An approach that promised to democratize design may have done the opposite. The results would, eventually, set Kirsch on a collision course with the scientific establishment. The rest of the board soon followed. I couldn't agree more. For example all of these combos should have near 100% success against hospitalization, death, and long-haul COVID symptoms: Proxalutamide and fluvoxamine Today, if we follow the CDC advice, nearly 100,000 people a month will die from COVID. In some cases, youd want to taper down the dosage. Here is the latest version. My favorite dosage is 50mg twice a day for 14 days. Where did it go wrong. They were giving covid patients the antidepressant fluvoxamine as soon as possible after diagnosis, based on anecdotes about the drug limiting the runaway immune response that causes many severe symptoms. There are now 5 independent observational studies that show that the drug works (2 in France, 1 in Germany, 2 in the US). As a health care journalist, I started off firmly in the wait-and-see camp on mRNA vaccines. iRobot said it had consent to collect this kind of data from inside homesbut participants say otherwise. But the confusion provided a fertile breeding ground for skeptics. Online Status. Most recent articles first. The NIH wrote a bullshit rejection because the FDA told them not to approve it. reach out to us at All the supporting observational studies were positive as well. Fluvoxamine is a very safe drug on market for 37 years, tens of millions of people have taken it, no record in scientific literature of anyone dying on overdose, and according to doctors that know the drug the best, about as dangerous as taking a Tylenol. Talking to Kirsch is an exhausting experience. This suggests that a 50mg BID loading dose for day one, followed by 50mg QD dose for the following 13 days should also be quite effective. This post was written to memorialize the corruption. . Every year, we pick the 10 technologies that matter the most right now. The evidence is solid. ). Compulsive fiddling with your mask? Every earlier study of fluvoxamine (such as observational studies) showed it work and the mechanism had been shown. , a non-profit known as the nations drug pricing watchdog, did a review of the evidence and determined that fluvoxamine evidence is superior to Molnupiravir. By Steve Kirsch Last updated: March 14, 2021 After I appeared on the60 Mi nut es story about fluvoxamine,I've received a lot of questions from people about how to treat COVID. We pretty much practice government agency opinion medicine all over the world now, with just a few exceptions. You see this with people who have a lot of money, who think that reflects their intelligence, Richman told me. If you wanna find someone to debate me for ten thousand dollars, or a thousand dollars, Im happy to do that, just for your benefit.. The medical community doesnt care about saving lives. What has alarmed many of the scientists associated with CETF, though, are Kirschs reactions to the work hes fundedboth successes and failures. Three of the four outpatient trials have been reported out: all were successful. But they will refuse to give it to you even after being proven in a Phase 3 trial that was approved by the WHO. We asked Steve to tone it down. I will . Molnupiravir followed patients for only 30 days because they know the drug is dangerous. I have never heard of a case it didn't work. Ms Tech | Pexels (hands); Kirsch (skirsch.com), Ivermectin has been falsely promoted as a covid treatmentbut for those who use the drug legitimately, seeing it become a piece of anti-vaccine misinformation is disconcerting, supports Technology Review's reporting on covid, anti-covid-vaccine, pro-ivermectin pundit, Roomba testers feel misled after intimate images ended up on Facebook, How Rust went from a side project to the worlds most-loved programming language. Kirsch and his wife, Michele, fund a charitable foundation, which by 2007 had given $75 million to different causes. No more. Medium revoked my account for life. We look for advances that will have a big impact on our lives and break down why they matter. Get your prescription in advance of getting COVID. Thirty minutes past the end of our scheduled time, he dropped his phone in the cupholder of his Tesla so that he could keep talking while he ran an errand. My website www.skirsch.io has tons of info on fluvoxamine with all the links. 4000fluvoxamine750 Note: normally I have lots of hyperlinks to all the sources, but Im pressed for time. My publicly shared concerns regarding the safety of the COVID-19 vaccines may have had a negative impact on my company, M10. Kirsch, though, often relies on the heartstrings to smooth over a lack of data. Here are my answers. just like ivermectin). This advice is now outdated. I only know of a few doctors who prescribe this off-label, all with 100% success rates. Most doctors wont use it until NIH greenlights it, no matter what the science says. Now weve lost the high ground, Morris told me. So why would we wait when lives are being lost? Physicians who use the drug for COVID now swear by it. The NIH never did a risk benefit analysis of this drug. Hes adept at debate, rapidly shifting the premise of a conversation to put the other person on the back foot. Its motivated out of his sense of keeping people safe and advancing health care.. The medical community did nothing (with a few exceptions like Dr. Seftel). I am not aware of a single case where taking the made things worse, e.g., person was doing fine BEFORE the drug and symptoms worsened after taking the drug. The data we have today with just 2 clinical trials (RCT and confirmatory RWE) is compelling. While these are stunning results, less than a dozen doctors in the US are prescribing fluvoxamine today. Paper reviewing the evidence and mechanisms of action for fluvoxamine: Lenze Phase 2 RCT published Nov 12, 2020: Seftel RWE trial that confirmed the Phase 2 trial published Feb 1, 2021. He is the inventor of the optical mouse and one of the first Internet search engines, Infoseek. Thats why they didnt even fund the fluvoxamine trial, he told me. You will be wired for 24 hours if you dont heed my advice. 90,000 Americans will die from COVID in just the next 3 weeks, a third of recovered patients from COVID will return to the hospital within 5 months and 1 in 8 die, Lenze fluvoxamine RCT that was published in JAMA. Hes refused to accept the results of a hydroxychloroquine trial that showed the drug had no value in treating covid, for instance, instead blaming investigators for poor study design and statistical errors. Timing is everything with respect to outcomes. In the early days of the pandemic, as billions of dollars poured into the hunt for novel treatments and vaccines, veteran Silicon Valley entrepreneur Steve Kirsch did what hes always done: He went looking for an underdog. Steve Kirsch: Vaccine Killing Millions, Treatments, VAERS, 5-Month Death Signal, Mystery Clots Embed 7.76K 31 'This Has Cost Millions Of Lives': Steve Kirsch On Suppression Of Repurposed Drugs And A Spike In Deaths 5 Months After Vaccine Rollout By Jan Jekielek American Thought Leaders / The Epoch Times November 24, 2022 Show more [https://www.quora.com/What-is-the-current-treatment-for-Covid-19/answer/, The most urgent need in the country right now is to reduce. Hes very convincing. It cant be more clear than this. (The fund borrows its nonprofit status from the 501(c)(3) Rockefeller Philanthropy Advisors, which managed its money until it quit, according to the Daily Beast; neither organization is related to the Rockefeller Foundation, which supports Technology Review's reporting on covid.). He retired at the largest pension in federal history. (Clayton Fox, Marty Makary, and Jeffrey Klausner). Waiting months for the phase 3 trial to complete is nuts. (The ivermectin data are trash, Feinberg told me. Entrepreneur Steve Kirsch who holds an early patent for the optical mouse decided to get involved in treating Covid. Early treatment with existing drugs is the fastest, most effective, and lowest. Kirsch told me that meta-analyses are a higher level of evidence than randomized controlled trials. When I responded that meta-analyses are only as good as the data they are based on, he said Id like to understand your source on that, because I cant find a source that says a phase 3 trial is greater evidence than a meta-analysis., When you characterize me, you need to say that Steve Kirsch doesn't go with majority votes on interpreting data.. This advice is now outdated. Fluvoxamine for COVID-19 summary Steve Kirsch Executive Director COVID-19 Early Treatment Fund stk@treatearly.org 650-279-1008 Google Docs This is a more comprehensive look at the key evidence supporting fluvoxamine: Fluvoxamine for COVID-19 Im not going to make the same mistake again.. Doctors have no excuse for not prescribing. That was a lie. Its board told him that if he wanted to remain part of the company he would have to stop making public anti-vaccine statements. Summary of key evidence. Nov 12: Steve Kirsch gives talk on CETF to HarvardBusiness School hosted by Dr. Seftel Nov 13:Mass COVID outbreak at GGF is now publiclyknown Nov 16: Seftel, the track physician at GGF, startsFLV . Be warned!. He felt like he in good conscience had to speak out about covid, and so he made the decision to separate himself from M10, says Char, who has known Kirsch since the 1980s. Dosage there is 30mg once a day. So you can address your OCD and if you get COVID, youll can up the dose. Some countries dont have fluvoxamine so this is the alternative. By Steve Kirsch in fluvoxamine Feb 14, 2021 The case for fluvoxamine for treating COVID-19 A very short op-ed arguing for using fluvoxamine against COVID. Kirsch and his group received a fresh wave of attention off hopeful trials of the antidepressant fluvoxamine, which ultimately won him a spot on 60 Minutes in March. Dr. Eric Lenze: So the results were really pretty. Another is to identify an asteroid that is going to hit the planet.. I disagree with his interpretation of the data regarding several medicines and strongly disagree with his anti-vaccine nonsense, Boulware wrote to me. The 50mg BID dose was quite effective, but it has to be started early (as soon as symptoms start). People who report not tolerating the drug are typically prescribed too high a dose. To date, the #1 drug with the most evidence to make a significant difference, without any doubt, is fluvoxamine. In September, Kirsch emailed Morris asking him to estimate the maximum number of deaths caused by vaccines. Completely avoid caffeine, alcohol, tylenol, and benadryl. To scientists, giving fluvoxamine a chance means running a large trialnot giving it to individual patients in the clinic, off-label and outside the context of active data collection and analysis. Instead, it erodes confidence in our government to provide timely advice that is in the public interest. He might be a good snake oil salesman., I experienced this myself when, on one call, we discussed several studies. Note that some of these articles are inaccurate. The NIH picks the drug that makes the most money for the drug companies regardless of long-term safety Molnupiravir! All have had a 100% success record in keeping their patients out of the hospital. Personal life. David Boulware, a researcher at the University of Minnesota, received $125,000 to test the drug against covid. A few months ago, Kirsch suddenly stopped promoting hydroxychloroquineeven scrubbing it from the CETFs official list of trials it has funded. But an Editor's Note urged physicians to treat this as a hypothesis and not as a basis for clinical decision-making. Ive used it personally at 50mg twice a day and experience no adverse events at all. The FDA is will take months to deliberate on the fluvoxamine EUA application that we submitted on January 29. This looks ominous, but it harmless. Do they sell it anywhere? We didnt come up with better mouse technology than Microsoft did. I asked to give a talk about COVID at MIT, but they couldn't find a faculty member to sponsor it. This looks ominous, but it harmless. this is NOT about the science. Thats why they didnt change their recommendation when the Phase 3 trial was published in Lancet. Nobody in the medical community is speaking out about how hypocritical the medical community is for ignoring the positive Phase 3 trial results and instead following whatever the NIH or FDA says. As of November 13, fluvoxamine has been proven to work in every trial that has published results, including outpatient and inpatient studies. We could have saved a lot of lives. . Those days are gone. Three of the four outpatient trials have been reported out: all were successful. Dr. Seftel's paper has been accepted for publication and will appear in OFID in early February. If you are experiencing any odd adverse reactions, youll need to consult with your doctor ASAP. If you do have a side-effect, it is usually mild nausea which goes away when you stop taking the drug. The alarming article cited the claims of two anti-vaxxers, Steve Kirsch and Dr. Robert Malone. Other SSRIs work as well, but fluvoxamine activates the Sigma-1 receptor the most of the SSRIs which is why it was chosen. I think we did rigorous reviews of proposals for research.. It is very important to educate doctors because most people rely on their doctors for advice. So you can address your OCD and if you get COVID, youll can up the dose. It used to be that a Phase 3 study would do it. I didnt intend to spend a lot of time on Steve in particular, but that video was so influential.. Comparison with molnupiravir. The agency quickly slapped down the comments from Kirsch, a tech mogul with a fortune once estimated at $230 million, even as the claims triggered a flurry of false social-media posts attributing. Is that really true? Hes also publicly railed against what he claims is a campaign against drugs like fluvoxamine and ivermectin. Dosing. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. Today, if we follow the CDC advice, nearly 100,000 people a month will die from COVID. You can use fluoxetine as well (aka Prozac). MD, MPH; Steven C. Marcus, PhD. It does not matter how many lives will be saved.